Atrial Fibrillation and Flutter, Hyperthyroidism, Hypothyroidism
Conditions
Keywords
Atrial Fibrillation and Flutter, Hyperthyroidism, Hypothyroidism, catheter radiofrequency ablation
Brief summary
Patients with hyperthyroidism or hypothyroidism are often combined with atrial fibrillation, but after the stabilization of thyroid hormone levels after treatment, the patients' atrial fibrillation still persists. Radiofrequency ablation of the atrial fibrillation as one of the treatment options for atrial fibrillation has been widely used in the clinic, and has significant efficacy in maintaining sinus rhythm, improving cardiac function, and improving the prognosis of patients. However, there is a lack of clinical monitoring data on radiofrequency ablation of atrial fibrillation in patients who have combined thyroid dysfunction and have stabilized their thyroid hormone levels after treatment.
Detailed description
In patients recommended by guidelines for atrial catheter radiofrequency ablation of atrial fibrillation, catheter radiofrequency ablation was performed after exclusion of contraindications, and was observed and compared between patients with comorbid pre-existing thyroid hormone disorders and patients without comorbid atrial fibrillation after radiofrequency ablation:1: time to sexual rhythm maintenance: incidence of cardiac-related complications and incidence of noncardiac-related complications within 3 months and 1 year,2: walking distance on a six-minute walk test within 3 months,1 year, comparison of percent left ventricular ejection fraction, and comparison of left ventricular diastolic diameter at the time 3 months,1 year,.To comprehensively assess the efficacy and safety of catheterized radiofrequency ablation of atrial fibrillation in patients with comorbidities of prior thyroid hormone disorders.
Interventions
PROCEDURECatheter Ablation
catheter radiofrequency ablation therapy for atrial fibrillation involves the use of ablative energy to destroy the cardiomyocytes at the opening of the pulmonary veins, which blocks the electrical conduction pathway between the pulmonary veins and the left atrium, so that atrial fibrillation no longer occurs.
Sponsors
The Second Affiliated Hospital of Jiaxing University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Atrial Fibrillation Requiring Catheterized Radiofrequency Ablation （Class I Recommendation）
Exclusion criteria
Atrial Fibrillation Requiring Catheterized Radiofrequency Ablation Class I Recommendation With Coexisting Contraindications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Non-Cardiac Related Complications | 3 month and 1year after cardiac radiofrequency ablation | Neurological Complications Asymptomatic cerebral embolism TIA Perioperative stroke Permanent phrenic nerve injury Digestive Complications Esophageal Injury Gastric Hyperdynamics Atrioesophageal Fistula Vascular Complications Hematoma Arteriovenous fistula Pseudoaneurysm Severe pulmonary stenosis |
| Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation | 3 month and 1year after cardiac radiofrequency ablation | Inability to maintain sinus rhythm, recurrent atrial fibrillation or atrial flutter |
| Postoperative heart-related complications | 3 month and 1year after cardiac radiofrequency ablation | Cardiac perforation/cardiac tamponade Coronary artery stenosis/occlusion Pericarditis Atrial stiffness syndrome Coronary artery air embolism Pseudoaneurysm Severe pulmonary stenosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LVEF% | 3 month and 1year after cardiac radiofrequency ablation | Per-beat output as a percentage of ventricular end-diastolic volume (cardiac preload) |
| 6-minute walk test | 3 month and 1year after cardiac radiofrequency ablation | Left atrial diastolic diameter |
| Left Atrial Internal Diameter | 3 month and 1year after cardiac radiofrequency ablation | Left atrial anteroposterior and superior-inferior diameters |
Other
| Measure | Time frame | Description |
|---|---|---|
| Thyroid hormone levels | 3 month and 1year after cardiac radiofrequency ablation | hyperthyroidism Hypothyroidism A change in thyroid hormone status from stable to unstable. |
Countries
China
Outcome results
None listed