Patient Reported Outcome Measures, Pulmonary Surgical Procedures
Conditions
Keywords
Inferior pulmonary ligment, Pulmonary Surgical Procedures, Patient Reported Outcome Measures
Brief summary
The investigators conducted a muti-centres randomized controlled clinical trial to explore the effect of preservation of inferior pulmonary ligment compared with dissection.
Detailed description
Dissection of the inferior pulmonary ligament (IPL) has been a common practice in upper lobectomy to facilitate the expansion of the remaining lung, reduce dead space after resection, and minimize complications such as pleural effusion and pulmonary infection. However, studies have found that IPL dissection does not improve patient outcomes. On the contrary, releasing the restriction may lead to excessive movement of the remaining lobes, resulting in significant changes in bronchial angles and lung volume, which can worsen pulmonary function and increase postoperative symptoms. Most existing studies are retrospective, providing relatively low-level evidence. Moreover, previous research has primarily focused on radiographic outcomes and pulmonary function tests results, while the effect on patients' symptom burden has been largely overlooked. From the patient's perspective, symptom burden might be more significant, reflecting the clinical value of changes in radiographic and functional indices. In this study, the investigators applied patient-reported outcomes to measure symptoms. Combined with pulmonary function results and radiological outcomes, the investigators compared the clinical value of preserving versus dissecting the IPL in upper lobectomy.
Interventions
PROCEDUREPreserving IPL during surgery
IPL was preserved during surgery
Sponsors
Guangdong Provincial People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients underwent upper lobe resection 2. Patients could complete our questionnaires
Exclusion criteria
1. Previous history of ipsilateral lung surgery 2. Patients who underwent pleurodesis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cough score postoperation | up to 3 months | The investigators used PSA-LUNG questionnaire to assess patients symptom burden after surgery. Changing of cough score during 1 month postoperation was chosen as the primary outcome. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Other Symptom burden postoperation PSA-LUNG questionnaire | up to 3 months | Using PSA-LUNG questionnaire, the investigators assessed shortness of breath, pain, sleeplessness, annoy, and fatigue after surgery. |
| Radiological outcome | Day 1 after surgery; 1 month after discharge; 3 months after discharge | Changing of bronchial angels measured with chest x-ray examination or chest CT. |
Countries
China
Contacts
Primary ContactGuibin Qiao, MD
Outcome results
None listed