Sleep Deprivation
Conditions
Brief summary
This study aims at identifying neuroimaging markers of glymphatic function in humans.
Interventions
OTHERNo interventinon
No intervention is anticipated. This is an observational study.
Sponsors
Oregon Health and Science University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Inclusion criteria
* Ability to undergo MRI without anesthesia * Calculated GFR greater or equal to 60 mL/min/1.73 m2
Exclusion criteria
* Inability to obtain consent * Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant * Known allergic or hypersensitivity reactions to gadolinium * Three or more drug allergies from separate drug classes * Recent or expected beed for imaging with iodinated contrast * Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe * History of neurosurgical procedure or cervical surgery * Current use of anticoagulation medications * Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Contrast enhancement | 2 weeks | Measurement of contrast intensity in brain parenchyma |
Outcome results
None listed