Motoric Cognitive Risk Syndrome
Conditions
Keywords
Veterans, Mobility, Cognition, Sequential Multiple Assignment Randomized Trial
Brief summary
This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).
Detailed description
This study will involve therapeutic exercise treatments for Veterans with pre-clinical dementia syndrome. Participants will either participate in functional power training, music-based walking training, or a combination of both. The study will use a sequential multiple assignment, randomized trial (SMART) design. Successful completion of this study will lay the foundation for subsequent research trials, contributing to valuable evidence for personalized rehabilitation medicine for older Veterans.
Interventions
BEHAVIORALFunctional Power Training (FPT)
Participants will receive twice weekly FPT, a progressive functional-based exercises that target optimizing leg force production and leg velocity.
BEHAVIORALMusic-Based Digital Therapy (MBDT)
Participants will receive twice weekly MBDT, a technology-driven gait training that is grounded in evidence-based rehabilitation treatment, rhythmic auditory stimulation.
BEHAVIORALFPT + MBDT
For non-responders who were randomized to augment treatment, they will receive combined FPT and MBDT treatment.
Sponsors
VA Office of Research and Development
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Sequential Multiple Assignment Randomized Trial (SMART)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age 65 2. Receiving VA primary care 3. Community-dwelling 4. Motoric Cognitive Risky Syndrome i. Slow gait speed ii. Subjective cognitive concerns/complaints
Exclusion criteria
1. Non-English speaking 2. Presence of a terminal disease 3. Major medical problem 4. Myocardial infarction or major surgery in the previous 3 months 5. 3-point walking pattern 6. Dementia diagnostic 7. Mobility disability
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Enrollment/Baseline | Enrollment | Enrollment will be defined as the number of participants who were recruited and consented to the study. |
| Retention | Baseline to end of 12-week treatment | Retention will be defined as the number of participants who completed the 12-week exercise treatment. |
| Compliance | Baseline to end of 12-week treatment | Compliance will be defined by the proportion of completed treatment sessions. |
| Acceptability | End of 12-week treatment | Acceptability will be recorded by conducting interviews with participants who completed the 12-week exercise treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gait Speed | Baseline to end of 12-week treatment | Change in gait speed will be assessed after 12-week exercise treatment. |
Countries
United States
Contacts
CONTACTElisa Ogawa, PhD MS BS
PRINCIPAL_INVESTIGATORElisa Ogawa, PhD MS BS
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Outcome results
None listed