Graves Disease
Conditions
Brief summary
Introduction: A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD). Methodology: A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.
Interventions
DIETARY_SUPPLEMENTVitamin D supplements
70 mcg/day (equal to 2800 IU) of cholecalciferol
DIETARY_SUPPLEMENTPlacebo
Matching Placebo
Sponsors
Frontier Medical and Dental College, Abbotabad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Grave's Disease * either starting or about to start anti-thyroid medication (ATD)
Exclusion criteria
* Chronic granulomatous disease * hypercalcemia * poor renal function (eGFR \< 45 ml/min) * the presence of malignant disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle Strength | base line and after 3months | Hand Grip strength was measured using dynamometer |
Countries
Pakistan
Outcome results
None listed