Hypoparathyroidism
Conditions
Brief summary
Endocrine determinants of renal function in patients with hypoparathyroidism on conventional treatment: a cross-sectional study (ENDORSE)
Interventions
DIAGNOSTIC_TESTBlood sample and urine collection
Blood sample and urine collection as per clinical practice
Sponsors
IRCCS San Raffaele
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* age ≥ 18 years * diagnosis of chronic (≥ 1 year) post-surgical and autoimmune hypoparathyroidism, as established with undetectable or insufficient PTH concentration in relation to the presence of hypocalcemia * patients being treated with calcitriol or alfacalcidiol * patients able to sign the written informed consent
Exclusion criteria
* pregnancy * severe renal failure requiring dialysis treatment * macroproteinuria * use of antihypertensive drugs such as thiazides, ACE inhibitors, sartans, beta and alpha blockers, and antialdosterone drugs * pazients affected by diabetes mellitus- insulin-treated
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of renal failure and altered PTH-related renal active hormonal axis in patients with hypoparathyroidism | 12 months | Evaluation of the prevalence of renal failure and altered PTH-related renal active hormonal axis in patients with hypoparathyroidism (hypoPTH) in conventional treatment with calcium and vitamin D |
Countries
Italy
Outcome results
None listed