Infectious Complications (Epidural Abscess or Meningitis), Obstetrical Neuraxial Anaesthesia
Conditions
Keywords
Primary immunodeficiencies, Neuraxial anaesthesia, Obstetrical anaesthesia, Epidural abscess, Meningitis
Brief summary
The purpose of this study is to evaluate if neuraxial anesthesia (epidural or intradural anesthesia) used during childbirth is associated with more frequent infectious complications in patients with primary immunodeficiencies (PID).
Detailed description
Neuraxial anaesthesia (epidural or intradural) is often used to alleviate pain during labour and childbirth. Although extremely efficient and safe, rare but serious infectious complications such as epidural abscess or meningitis can occur afterwards. Patients with PID tend to have a greater risk of infectious complications than the general population. With the progress of medical care in those pathologies, female patients are now giving birth more often. The use of neuraxial anaesthesia and the associated infectious complications have never been studied in this population. The investigators intend to review the medical records of PID patients who gave birth in an APHP hospital in the last 10 years to evaluate the use of neuraxial anesthesia and the frequency of infectious complications associated with neuraxial anesthesia.
Interventions
OTHERNon applicable
Non applicable (data collection)
Sponsors
URC-CIC Paris Descartes Necker Cochin
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Female patient included in the CEREDIH national register * Aged \> 18 years
Exclusion criteria
* Refuse to participate * Deceased * Minor * under judicial protection * obstetric file not available
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants who develop a local or systemic infection, such as an epidural abscess or meningitis, within 28 days after receiving neuraxial anesthesia during delivery | 28 days post-partum | Occurrence of a local or systemic infection post-neuraxial anesthesia within 28 days after delivery / Infectious complication after obstetrical neuraxial anesthesia / Epidural abscess or meningitis after neuraxial anesthesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of Alternative Pain Relief Methods Utilized Due to Contraindications Linked to Primary Immunodeficiency | During labour | Use of an alternate method for pain-relief during childbirth / Use of another method of pain relief due to a contraindication linked to primary immunodeficiency |
| Rate of Antibioprophylaxis Administration During Neuraxial Anesthesia | up to 24 hours after birth | Use of a antibioprophylaxis when performing neuraxial anesthesia |
| Number of cases where maternity anesthetists identify contraindications to performing neuraxial anesthesia in patients with primary immunodeficiency | During labour | Possible occurrence of contraindications identified by the maternity anesthetist to the performance of neuraxial anesthesia linked to primary immunodeficiency |
Countries
France
Outcome results
None listed