Borderline Personality Disorder
Conditions
Keywords
fMRI neurofeedback, mindfulness
Brief summary
The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).
Detailed description
The focus of this study is Aim 1.
Interventions
BEHAVIORALmindfulness-based Neurofeedback
Participants will complete one session of mindfulness-based fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.
OTHERcontrol Neurofeedback
Participants will complete one session of control fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.
Sponsors
Yale University
Connecticut Mental Health Center
National Institute of Mental Health (NIMH)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* age 18-60, * be able to provide written informed consent, * meet criteria for BPD on semi-structured clinical interview, * able to plan to keep any prescribed medications and psychotherapy constant during the study * fluent in English.
Exclusion criteria
* current DBT psychotherapy outside the study * lifetime primary psychotic disorder * manic episode in the last one year * developmental disorder (e.g. autism) * history of learning disorder * severe substance use disorder in the last 3 months * active suicidal ideation with intent or plan in the past 3 months * history of major medical or neurologic disorder * MRI contraindications, including pregnancy * poor performance on reading task (WRAT \> 11 errors) * newly prescribed medications in the past 8 weeks * daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics) * any scheduled daily benzodiazepines * change in psychotherapy type or frequency in the past 12 weeks. * At the discretion of the study PI Eligibility will be determined by study personnel.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in within-Default Mode Network (DMN) resting state functional connectivity after one session of neurofeedback (NF) | From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day | Defined as within-DMN connectivity as the resting state seed-based connectivity between core nodes of medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). Change = post-NF within-DMN connectivity - pre-NF within-DMN connectivity. |
| Change in DMN-Frontoparietal Control Network (FPCN) anticorrelation in resting state functional connectivity data after one session of neurofeedback | From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day | Defined as DMN-FPCN anticorrelation as the fMRI seed-based connectivity from mPFC to dorsolateral prefrontal cortex (dlPFC)). Change = post-NF mPFC-dlPFC anticorrelation - pre-NF mPFC-dlPFC anticorrelation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in state mindfulness on State Mindfulness Scale (SMS) score on same day after neurofeedback. | From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day | The State Mindfulness Scale (SMS) is a validated self-reported 21 item instrument assessing state mindfulness over the past 15 minutes. Possible scores range from 21 (not mindful) to 105 (very mindful). |
Countries
United States
Contacts
CONTACTSarah K Fineberg, MD PhD
PRINCIPAL_INVESTIGATORSarah K Fineberg, MD PhD
Yale University
Outcome results
None listed