Cerebrovascular Circulation, Magnetic Resonance Imaging
Conditions
Keywords
Magnetic Resonance Imaging, Exercise, Brain Blood Flow
Brief summary
Brain blood flow will be measured during exercise using magnetic resonance imaging.
Detailed description
Over 6 million Americans are living with Alzheimer's disease and related dementias and this number is expected to reach over 13 million by 2060. Thus, there is an urgent need for interventions to prevent the development and progression of Alzheimer's disease and related dementias. Regular exercise is currently the most promising strategy as it is repeatedly shown to have neuroprotective benefits. Evidence suggests that the neuroprotective effects of exercise is the result of improved health of blood vessels. Despite the vast amount of evidence on the benefit of exercise on the peripheral vasculature, there is little information regarding brain vascular responses during exercise. This study will investigate the impact of exercise at varying intensities on brain blood flow during exercise, and will also examine the influence of age and sex. This record represents a younger cohort for the study represented in NCT05864950.
Interventions
DEVICEMRI
Participants will undergo an MRI scan while performing exercise at two intensities (light and moderate/vigorous) using an MRI-compatible stepper device.
Sponsors
University of Wisconsin, Madison
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men or women between the ages of 20-40 years old * Demonstrate an exercise history of engaging in aerobic physical activity at least 3 times per week for a minimum of 30 continuous minutes * Have experience using cardiovascular exercise equipment (e.g., treadmill, elliptical, upright or recumbent bicycle, stair-stepper)
Exclusion criteria
* Outside of specified age range * Do not have experience using cardiovascular exercise equipment * Do not meet the physical activity criteria * Present with a history or evidence of hepatic, renal, hematological disease, cardiovascular disease including uncontrolled hypertension, peripheral vascular disease, stroke/neurovascular disease, and diabetes * have a body mass index ≥35 kg/m2 * are ≥ 71 inches (180 cm) in height * have any contraindications to MRI * currently use or have a history of use of tobacco or illegal substances * have current and/or a history of depression or other mood related disorders (those with mild depression and/or anxiety that is controlled with medication and/or therapy will not be excluded) * vulnerable populations (e.g., pregnant women, prisoners, individuals lacking capacity to consent) * if the desired moderate/vigorous exercise intensity corresponds to \> 350 watts on the stepper device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral Hemodynamics | One study visit, up to 120 minutes | The change in cross-sectional area of the cerebral arteries during exercise will be measured with MRI. |
| Cerebral Blood Flow | One study visit, up to 120 minutes | The change in intracranial blood flow during exercise will be measured with MRI. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJill N Barnes, PhD
University of Wisconsin, Madison
Outcome results
None listed