Osteoarthritis, Knee
Conditions
Keywords
intraarticular injection
Brief summary
Total knee arthroplasty is a safe procedure with excellent outcome. In recent years, simultaneous bilateral total knee arthroplasty has become more popular. In views of enhanced recovery after surgery, intraarticular cocktail injection for pain control has been developed. However, the safety accumulation dose for simultaneous bilateral knee injection is still an issue. Recently, adding magnesium sulfate to intraarticular cocktail injection in unilateral total knee arthroplasty has been proved effective for prolong pain control. We tempt to conduct a double blinded study to evaluate that whether adding magnesium sulfate intraarticular cocktail injection to one of the knees in simultaneous bilateral total knee arthroplasty patient could effectively decrease pain score with less analgesia dose or not.
Interventions
DRUGMagnesium sulfate
adding 300mg magnesium sulfate into cocktail injection
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* bilateral knee advanced osteoarthritis or osteonecrosis who tend to receive simultaneous bilateral total knee arthroplasty
Exclusion criteria
* hypersensitivity to magnesium sulfate * hypermagnesemia * severe cardiac, hepatic or renal compromised
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score | day 0, day 1, day 2, day 3, day 7 |
| muscle power | day 0, day 1, day 2, day 3 |
| Straight leg raised test | day 0, day 1, day 2, day 3 |
| active range of motion | day 0, day 1, day 2, day 3 |
Secondary
| Measure | Time frame |
|---|---|
| Magnesium level in blood | day 0, day 1 |
| Calcium level in blood | day 0, day 1 |
Contacts
Primary ContactShih Hui Peng
Outcome results
None listed