Transient Receptor Potential Channels

Transient Receptor Potential Channels in Human Skin

Status

Enrolling by invitation

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06444594

Acronym

TRP

Enrollment

Registered

2024-06-05

Start date

2024-07-17

Completion date

2027-12-31

Last updated

2026-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging

Brief summary

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Interventions

DRUGTRPM8 Agonist

menthol gel 4-10%

DRUGTRPV1 Agonist

camphor gel 5-20%

DRUGTRPV4 Agonist

capsaicin gel 0.05-1%%

DRUGTRPM8, TRPV4, TRPV1 Agonists

menthol (4-10%), capsaicin (0.05-1%), camphor (5-20%)

OTHERVehicle gel

Inactive vehicle gel

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* 18-85 years old. * Women will not be pregnant and/or breastfeeding.

Exclusion criteria

* Currently pregnant or breastfeeding * Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime) * Known skin allergies or current rash, skin disease, disorders of pigmentation * Diabetes * Body mass index \>35kg\*m-2 * Using calcium channel blockers * Raynaud's syndrome * Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive * Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin

Design outcomes

Primary

Measure	Time frame	Description
Skin blood flow during slow local heating	75 minutes	Laser doppler flowmeter to measure skin blood flow during a slow local heating of the skin
Somatosensory perception	every 5 minutes for 120 minues	heat and cold perception using a visual analog scale
algometer measurement	every 30 minutes for 120 minutes	pain pressure thresholds

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORLacy Alexander, Ph.D.

Penn State University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 28, 2026