Cardiac Resynchronization Therapy
Conditions
Brief summary
The objective of this clinical study was to evaluate the impact of Multipoint Pacing (MPP) and SyncAV programming on ventricular electrical activation time and activation sequence using noninvasive electrocardiographic imaging (ECGi) in patients receiving cardiac resynchronization therapy (CRT).
Interventions
DEVICEMPP + SyncAV
Cardiac resynchronization therapy (CRT) features of MultiPoint Pacing (MPP) and SyncAV (dynamic atrioventricular delay programming) enabled.
Sponsors
Abbott Medical Devices
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients previously implanted with a SyncAV and MPP-enabled Abbott Quadripolar CRT pacing system * Patient must be \> 18 years of age, able to provide informed consent and willing to comply with study requirements * Sinus (or atrial paced) rhythm with intact AV conduction with PR interval ≤ 250 ms * Patient has documented Left Bundle Branch Block (LBBB)
Exclusion criteria
* Resting heart rate \> 100 bpm * AV Block (1st degree with PR\> 250 ms, 2nd or 3rd degree) * Documented persistent atrial tachycardia or atrial fibrillation at the moment of enrollment or patients not likely to remain in sinus (or atrial paced) rhythm for the duration of the study * Recent (\< 3 months) myocardial infarction, ablation, electrolyte imbalance, or any condition within the last 90 days that would contraindicate for CRT programming changes in the opinion of the investigator * Women who are pregnant or plan to become pregnant during the study course
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular activation time | 1 day | Evaluate acute changes in left ventricular (LV) electrical activation time measured with ECGi resulting from various CRT pacing configurations with MPP and SyncAV |
Countries
United States
Outcome results
None listed