Obsessive-Compulsive Disorder
Conditions
Keywords
obsessive-compulsive disorder, natural psychotherapy
Brief summary
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
Detailed description
1. To evaluate the cognitive function, Cognitive control, emotion and other aspects of neurosis patients, and to understand and master the cognitive behavior indicators of this population. 2. Investigate the pathological mechanism of neurotic patients from the aspects of electroencephalic graph/functional magnetic resonance imaging (EEG/fMRI) and biology. 3. To investigate the therapeutic effect of natural psychotherapy on cognitive impairment and related mood, sleep and symptom intervention in neurotic patients. In order to achieve the symptoms of neurosis patients, cognitive impairment and related mood and sleep intervention and promotion, while providing a scientific basis for neurosis rehabilitation.
Interventions
Draw ideas from traditional Chinese culture, learn from the practice of Morita therapy in Japan, and create local practice experience. At the same time, a variety of research methods such as cognitive assessment and brain imaging were used to establish the scientific, professional and objective evaluation indexes of the therapy.
Sponsors
Xiang Yang Zhang
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Have a diagnosis of obsessive-compulsive disorder or compulsive behavior * Duration of symptoms for not less than 12 months * Age 15-60 years old. * You can participate in the whole experiment and offline assessment in Beijing
Exclusion criteria
* Documented disease of physical diseases including, but not limited to stroke, tumor, Parkinson's disease, Huntington's disease, seizure, epilepsy, history of brain trauma * Subjects who suffered from alcohol or illegal drug abuse/dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Obsessive-compulsive symptoms | Baseline, 12 weeks | Obsessive-compulsive symptoms were assessed according to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), The total score ranges from 0 to 40, with higher scores indicating more severe symptoms. |
| Cognitive function | Baseline, 12 weeks | Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability. |
| Mood and behavior | Baseline, 12 weeks | Mood changes judged using gait and face recognition |
| ERP components associated with cognitive function | Baseline, 12 weeks | To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis |
| rest fMRI in Obsessive-compulsive patients | Baseline, 12 weeks | The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity：FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences. |
| Behavioral inhibition | Baseline, 12 weeks | behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability. |
Countries
China
Contacts
Primary ContactZhang Y Xiang, M.D., Ph.D
Outcome results
None listed