Choroid Diseases
Conditions
Keywords
Coronary Artery Disease, Choroid, Gensini Score, Optical Coherence Tomography
Brief summary
Purpose: To investigate any relationship between choroid thickness (CTh) and coronary artery disease (CAD), particularly in its earlier stages before clinically evident. Design: Retrospective, cross-sectional observational study Methods: Setting: The study was performed in two institutions; patients were recruited in Balikesir City Hospital. The ophthalmological examinations and coronary angiograms were performed in Balikesir City Hospital. The analysis of the coronary angiograms including Gensini scoring were conducted in Bursa Education and Research Hospital. Study Population: The study group comprised 68 patients with documented CAD and 60 healthy control subjects. Patients with high myopia, cataracts, retinal vascular disease, retinal surgery, retinal dystrophy, laser photocoagulation, intravitreal anti-VEGF treatment, glaucoma, uveitis, retinal disorders, any systemic diseases were excluded from the study groups. Observation Procedure: Refractive examination, corrected visual acuity, intraocular pressure measurements, anterior and posterior segment examinations. Following measurements of macular thickness and retinal nerve fiber layer, choroidal thickness of both eyes was assessed by enhanced depth imaging optical coherence tomography.
Interventions
DIAGNOSTIC_TESTOCT
Enhanced depth imaging optical coherence tomography (EDI-OCT) using the Heidelberg Spectralis HRA + OCT (Heidelberg Engineering, Inc., Franklin, MA, USA)
Sponsors
Bursa Yuksek Ihtisas Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Normal coronaries at coronary angiography for healthy control group * Without any coronary artery disease equivalent diseases such as peripheral artery disease, cerebrovascular disease and stroke for healthy control group * Ability to give informed consent for the study * Coronary artery disease with stenosis detected in coronary angiogram for coronary artery disease group
Exclusion criteria
* High myopia (\> 6D) * Cataracts * Retinal vascular disease * Retinal surgery * Retinal dystrophy * Laser photocoagulation * Intravitreal anti-VEGF treatment * Glaucoma * Uveitis * Retinal disorders (comprising diabetic macular edema, diabetic/hypertensive retinopathy, vein occlusions, retinal dystrophy, epiretinal membrane, vitreomacular traction, age-related macular degeneration) * Any systemic diseases * Obesity (body-mass index ≥30 kg/m²)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Choroidal thickness in Healthy Subjects | 1 day | micron |
| Choroidal thickness in patients with coronary artery disease | 1 day | micron |
Countries
Turkey (Türkiye)
Outcome results
None listed