Breast Cancer Female
Conditions
Keywords
Risk rejection, Screening behaviour
Brief summary
The Understanding and Addressing Rejection of Personalized Cancer Risk Information study is a longitudinal study conducted to understand the nature of phenomenon of personalized cancer risk rejection in the context of mammography screening.
Detailed description
The Understanding and Addressing Rejection of Personalized Cancer Risk Information study seeks to understand the nature of the phenomenon of personalized cancer risk rejection in the context of mammography screening by 1) identifying demographic and psychological factors associated with risk rejection and 2) identify how risk rejection influences risk-concordant mammography screening behavior. The study will test a priori theory-derived hypotheses about the precursors of risk rejection and the influence of rejection on real-life screening decision making. The Breast Cancer Risk Assessment Tool (BCRAT) will be used to asses participant's breast cancer risk. This model is designed to estimate breast cancer risk in women 35-84, and uses the following predictors: 1) age, 2) age at first menstrual period, 3) age at first live birth, 4) first-degree relatives with breast cancer, 5) previous breast biopsy with atypical hyperplasia, and 6) race/ethnicity. Participants will be required to complete the baseline survey in which they receive their BCRAT model risk estimate and respond to that risk estimate. They will then complete a 12-month follow-up survey.
Interventions
BEHAVIORALPresentation of personal breast cancer risk estimate
All participants will be presented with their personal breast cancer risk estimate, calculated using the Gail Model
Sponsors
University of Colorado, Denver
National Cancer Institute (NCI)
National Institutes of Health (NIH)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
39 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
1. Female sex 2. Age 39-74 (i.e., people who are eligible for routine breast cancer screening and for whom guidelines recommend an informed, risk-based decision) 3. English literacy
Exclusion criteria
1\. Prior diagnosis of 1. breast cancer 2. Ductal carcinoma in situ (DCIS) 3. Lobular carcinoma in situ (LCIS) 4. Known BRCA1/2 gene mutation 5. Cowan syndrome 6. Li-Fraumeni syndrome 7. Having received previous chest radiation for treatment of Hodgkin's lymphoma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Risk rejection as measured by a numeric estimate. | At baseline survey | Participants are asked whether they agree or disagree with their Gail Model risk estimate. An open text box allows them to write the risk number that they believe is accurate for them. |
| Risk-concordant information seeking | At baseline survey | Participants will be given the opportunity to get more information about breast cancer screening, and will be given response options to receive information for women at lower than average risk, higher than average risk, or women with risk that is "about the same as a typical woman". Concordance is measured by agreement between the participants' actual risk estimate and the option that they choose. |
| Screening intentions | At baseline survey | Participants are asked their plans to get a mammogram in the next 12 months. The question is answered on a 5-point will-will not Likert scale. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORLaura Scherer, PhD
University of Colorado, Denver
PRINCIPAL_INVESTIGATORErika Waters, PhD
Washington University at St. Louis
Outcome results
None listed