Treatment of Tempromandibular Joint Anterior Disc Displacement With Different Materials

Hyaluronic Acid Versus Platelet Lysate in The Treatment of Temporomandibular Joint Anterior Disc Displacement With Reduction: A Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06441279

Enrollment

Registered

2024-06-04

Start date

2024-04-01

Completion date

2024-10-01

Last updated

2024-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

TMJ Disc Disorder

Brief summary

comparing the clinical efficacy of intra-articular injection of platelet lysate (PL), versus Hyaluronic Acid after arthrocentesis in the management of patients with anterior disc displacement with reduction.

Interventions

PROCEDUREintra-articular injection with Platelet lysate (PL).

2 ml of Platelet lysate will be deposited into the superior joint space (SJS) in the affected joint at the entry point slowly

PROCEDUREintra-articular injection with Hyaluronic Acid.

2 ml of Hyaluronic Acid will be deposited into the superior joint space (SJS) in the affected joint at the entry point slowly.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients that will be diagnosed with anterior disc displacement with reduction (ADDWR) both clinically and through magnetic resonance imaging scan (MRI). * Patients who will not respond to a previous conservative therapy. * Patients with pain in temporomandibular joints. * Patients with normal or limitation in mouth opening. * Patients with clicking sound.

Exclusion criteria

* Patients with previous invasive TMJ surgical procedures. * Patients with inflammatory or connective tissue diseases. * Patients with neurologic disorders. * Patients with history of bony or fibrous adhesion. * Patients having gross mechanical restrictions and condylar fractures. * Patients with psychological problems. * Patients receiving anti-coagulation treatment, non-steroidal anti-inflammatory drugs within 48 hours pre-operatively, corticosteroid injection at the treatment site within one month or systemic use of corticosteroids within 2 weeks.

Design outcomes

Primary

Measure	Time frame	Description
Maximum inter-incisal opening	6 months	Maximum inter-incisal opening will be measured by Vernier caliper and this will be recorded by photographs.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 2, 2026