Venous Congestion
Conditions
Keywords
congestion, portal vein pulsatility, ultrasound, fluid responsiveness, fluid tolerance
Brief summary
This study uses the portal vein pulsatility index (PVPI) to assess fluid intolerance amongst fluid responders.
Detailed description
This prospective observational study aims to use the portal vein pulsatility index (PVPI) to assess fluid intolerance in fluid responders. The investigators will enroll mechanically ventilated postoperative adult patients within 6 hours of ICU admission after cardiac surgery. Patients will undergo a Passive Leg Raising (PLR) test and Left Ventricular Outflow Tract (LVOT) recording using transthoracic echocardiography. The main objective is to predict fluid intolerance after a fluid challenge of 7 ml/kg Ringer Lactate over 10 minutes in initially tolerant fluid responders.
Interventions
7 ml/kg ml of Ringer's Lactate is given in 10 min amongst initially tolerant fluid responders.
Sponsors
Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Informed consent. * Mechanically ventilated patients within 6 hours after ICU admission following surgery who are considered for fluid administration to optimize haemodynamics. * Sinus rhythm.
Exclusion criteria
* A condition known to interfere with portal vein flow assessment or interpretation (liver cirrhosis or chronic hepatic disease, suprahepatic or portal vein thrombosis). * Any mechanical circulatory support. * Cardiac transplant. * Poor transthoracic echocardiographic window.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fluid Intolerance | 10 minutes after 7 ml/kg Ringer's Lactate | A portal vein pulsatility index greater than 50%, calculated as (Vmax - Vmin) / Vmax, with no upper limit and 0% as the minimum limit. Higher values indicate worse outcomes. Ultrasonographic portal spectral waveform was used to measure Vmax and Vmin. |
Countries
Romania
Outcome results
None listed