Chronic Rhinosinusitis (Diagnosis)
Conditions
Brief summary
The goal of our thesis is to design, develop and characterize a novel thermodynamically stable NE by spontaneous method intended for topical use. Subsequently, appraisal of nanoemulsified sesame oil formulation has been performed on the post-operative symptoms in CRS patients who have undergone ESS (endoscopic sinus surgery) combined with different types of nasal irrigation which may affect formulation efficacy.
Interventions
OTHERapplication of different topical nasal solutions
each group receives a type of nasal solution to detect if there is a difference in the outcomes in chronic rhinosinusitis patients
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Patient age between 18 and 60 years old. 2. chronic rhinosinusitis patients who have undergone endoscopic sinus surgery.
Exclusion criteria
1. Patients with history of allergy for sesame seed derivatives. 2. Patients with chronic diseases which affecting the process of healing (uncontrolled DM, renal failure and hepatic failure). 3. Patients with nasal granulomas. 4. Patients with invasive fungal rhinosinusitis. 5. Smokers. 6. Patients with history of radio and/or chemotherapy exposure. 7. Patients with systemic diseases affecting integrity of nasal mucosa (e.g. CF, scleroderma, Sjogren syndrome …).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sinonasal Outcome Test 22 (SNOT-22) | weekly for three months |
| Lund-Kennedy endoscopic grading system | once monthly for three months |
Countries
Egypt
Outcome results
None listed