Evaluation of Using Platelet-Rich Fibrin in Adult Pulpotomy

Clinical and Radiographic Evaluation of Platelets Rich Fibrin in Adult Pulpotomy: Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06437197

Enrollment

Registered

2024-05-31

Start date

2023-03-12

Completion date

2024-03-23

Last updated

2024-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible Pulpitis

Keywords

Pulpotomy, Platelet Rich Fibrin

Brief summary

The goal of this interventional randomized clinical trial is to evaluate the use of platelet rich fibrin in full pulpotomy in mature adult teeth. The main questions it aims to answer are: 1. Does the use of platelet rich fibrin in complete pulpotomy in mature permanent teeth will raise the success rate of full pulpotomy of adult teeth? 2. Does the use of cone beam computed tomography scans will be more effective in early detection of apical periodontitis than periapical radiographs? Participants will be asked to do the following: * Receive the pulpotomy treatment of their target tooth. * Record the pain score in the pain assessment chart. * Attend the follow-up visits. They'll receive a full pulpotomy treatment of their target tooth. Researchers will evaluate the usage of platelet rich fibrin in performing the pulpotomy procedure of adult teeth and if cone beam computed tomography scans will be more effective in early detection of apical periodontitis than periapical radiographs.

Interventions

PROCEDUREPulpotomy

Removal of the coronal pulp chamber in an adult teeth

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

25 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

1. Patient age: 25-35 years 2. Mature permanent premolar teeth with two separate roots. 3. Clinical diagnosis of irreversible pulpitis. 4. Patients without existing medical condition.

Exclusion criteria

1. Immature teeth. 2. Non-restorable teeth. 3. Non-vital Teeth. 4. Uncontrolled pulpal bleeding. 5. Periodontally affected teeth.

Design outcomes

Primary

Measure	Time frame	Description
Radiographic changes in periapical area using periapical radiographs.	6 and 12 months.	The radiographic changes was evaluated using periapical radiographs. the outcome was measured using the periapical index scoring 1,2,3,4 or 5 with 1 indicating normal and 5 indicates severe periodontitis with exacerbating features.

Secondary

Measure	Time frame	Description
Postoperative pain	Immediately, 24, 48, 72 hours and 7 days.	The postoperative pain was measured by modified modified Visual analog scale VAS which is is segmented into ten levels according to severity of pain, no pain (0), mild pain (1-3), moderate pain (4-6), or severe pain (7-10).

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026