Myocardial Infarction
Conditions
Keywords
exercise training, high intensity interval training, moderate intensity continuous training, heart rate variability, myocardial infarction
Brief summary
Heart rate variability (HRV) is impaired in patients after myocardial infarction. Most studies so far have proved chronic beneficial effects of different types of exercise on HRV parameters. Data on acute effects of different types of exercise training (e.g. high intensity interval training \[HIIT\] and moderate intensity continuous training \[MICT\]) is scarce. Patients in the study will perform both HIIT and MICT in a random order and in-between break of at least 48 hours. A 5-minute high resolution ECG recording will be performed before and immediately after both HIIT and MICT.
Interventions
OTHERType of Exercise
The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak. The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak.
Sponsors
University Medical Centre Ljubljana
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
HRV parameters analysis will be blinded regarding the exercise training modality.
Intervention model description
Each patient will have a bout of HIIT during one session and a bout of MICT during another session performed in a random order.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* myocardial infarction in last 120 days * sinus rhythm
Exclusion criteria
* contraindications for exercise training * uncontrolled dysrhythmias * Heart Failure NYHA IV stage * cognitive impairment * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HF parameter | 5-minutes high resolution ECG recording before and after an exercise session | High frequency domain of the HRV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LF parameter | 5-minutes high resolution ECG recording before and after an exercise session | Low frequency domain of the HRV |
| SDNN | 5-minutes high resolution ECG recording before and after an exercise session | Standard deviation of NN intervals |
| RMSSD | 5-minutes high resolution ECG recording before and after an exercise session | Root mean square of successive RR interval differences |
| pNN50 | 5-minutes high resolution ECG recording before and after an exercise session | Percentage of successive RR intervals that differ by more than 50 ms |
Other
| Measure | Time frame | Description |
|---|---|---|
| Non-linear methods | 5-minutes high resolution ECG recording before and after an exercise session | SD1, SD2 |
Countries
Slovenia
Contacts
Primary ContactMarko Novaković, MD, PhD
Outcome results
None listed