Chronic Obstructive Pulmonary Disease, Optical Coherence Tomography, Pulmonary Function
Conditions
Keywords
Chronic Obstructive Pulmonary Disease, Optical Coherence Tomography, pre-stage
Brief summary
The pre-stage of Chronic Obstructive Pulmonary Disease (Pre-COPD) is challenging to diagnose. However, identifying Pre-COPD is a crucial step in the prevention and management of COPD. Endobronchial optical coherence tomography showed the value of diagnosis in Pre-COPD and COPD in previous researchs.
Detailed description
We recruited COPD patients (stage I-II, n=15; stage III-IV, n= 15), Pre-COPD (n= 20) and healthy never-smokers (healthy human, n=21). Age,gender,BMI, smoking history, spirometry, chest computed tomography (CT), bronchoscopy and EB-OCT were performed. Inner luminal area (Ai) and airway wall area (Aw) of bronchi which inner perimeter was 10mm, 20mm and 30mm were measured using EB-OCT respectively. By analyzing and studying the above situation, we aim to discover the application value of OCT in Pre-COPD
Interventions
DEVICEOptical Coherence Tomography
Placing the probe of OCT in RB10c through the working channel of bronchoscope for real time dynamic scanning and collecting OCT parameters from participants in different groups.
Sponsors
Sichuan Provincial People's Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* non-smoking with normal lung function, no other pulmonary diseases besides pulmonary nodule as indicated by chest computed tomography (CT).
Exclusion criteria
* (1) patients with contraindication of bronchoscopy, (2) patients who are participating in other clinical studies, (3) patients with poor compliance who are believed by the researchers to be unable to cooperate for the completion of the examination and follow-up, and (4) women who were pregnant.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Representative EB-OCT images of airway disorders | baseline | Representative EB-OCT images(airway remodeling, mucosa thickening ) in CP，Pre-COPD and COPD |
| EB-OCT parameters in different stages of COPD | baseline | Inner luminal area (Ai，mm) and airway wall area (Aw,mm2) of bronchi which inner perimeter was 10mm, 20mm and 30mm were measured using EB-OCT respectively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pulmonary function test (FEV1 predicted %) | baseline | Baseline clinical characteristics |
| Baseline clinical characteristics | baseline | Age（year）, gender(Male/female), smoking history(yes/no) |
| MMEF 25/75 | baseline | Baseline clinical characteristics |
| FEV1/FVC ratio | baseline | — |
| BMI（Kg/m2)） | baseline | — |
Countries
China
Contacts
Primary ContactGuanghong G Zhou, Master
Backup ContactGuanghong G Zhou, Master
Outcome results
None listed