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Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence

Evaluation of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence

Status
Active, not recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06435832
Enrollment
98
Registered
2024-05-30
Start date
2024-05-16
Completion date
2024-06-01
Last updated
2024-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Osteitis

Keywords

Alveolar Osteitis

Brief summary

This intervention is the treatment of alveolar osteitis (alveolitis) with different effects, which occurs due to the formation of clot after extraction, which is one of the most common intervals after tooth extraction.98 healthy patients with molar and premolar teeth with indication for extraction were taken to the Recep Tayyip Erdoğan University Faculty of Dentistry, Department of Oral and Maxillofacial Diseases and Surgery clinic between May 2024 and June 2024 (age: 38 sessions: 19). -62) 113 teeth (85 molar, 28 premolar teeth) were treated with Spongostan placed in the tooth socket after extraction, spongostan with Chlorhexidine gel and spongostan with tranexamic acid, randomly distributed. After extraction, alveolitis was observed and evaluated prospectively using spongostan, chlorhexidine gel and tranexamic acid in the dental sockets. The researcher checked the participants on the 3rd and 7th days after the tooth extraction. The researcher recorded the pain and edema levels by asking the participants between 0 and 10 using the Visual Analogue Scale (VAS). The researcher filled in the forms for the presence of halitosis, trismus and exposed bone socket on the 3rd and 7th days (YES-NO). Permanent analyzes of the study were created with the SPSS package program.

Interventions

DRUGAbsorbable Gelatin

After tooth extraction, only saline irrigation was applied and a absorbable gelatin sponge was placed in the socket.

DRUGChlorhexidine

After tooth extraction, after irrigation with saline, 2% chlorhexidine gel was absorbed into gelatin sponges and placed into the socket.

DRUGTranexamic acid

Tranexamic acid 50mg/ml for injection after saline irrigation after tooth extraction solution into gelatin sponges was applied to the socket after it was cured.

Sponsors

Recep Tayyip Erdogan University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

1. Healthy individuals between the ages of 18-65 2. Molar and premolar teeth with extraction indication

Exclusion criteria

1. Against drugs or substances to be used in surgery (articaine, tranexamic acid, chlorhexidine) have allergies, 2. Those who used antibiotics 30 days before the dental extraction, 3. Clinical and radiological examinations in the operation area 30 days before dental extraction and/or on the day of the procedure. Any signs of pathology and infection (such as periapical pathology, pericoronitis), 4. Those who routinely use oral antiseptics, 5. Systemic fever, absence of growth such as lymphadenopathy (LAP), 6. Women are lactating or pregnant, 7. Using oral contraceptives, 8. Procedures that were not attended to control appointments (day 3-7) were not included.

Design outcomes

Primary

MeasureTime frameDescription
pain3.-7. daysscored on visual analog scale from 0 to 10
edema3. day - 7. dayscored on visual analog scale from 0 to 10
trismus3. day - 7. daymarked yes or no based on clinical examination
halitosis3. day - 7. daymarked yes or no based on clinical examination
alveolar osteitis3. day - 7. daymarked yes or no based on clinical examination
smoking habitoperated daymarked yes or no based on anamnesis
ageoperated daymarked yes or no based on anamnesis
tooth typeoperated daymarked yes or no based on clinical examination

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026