Pituitary Diseases
Conditions
Brief summary
The goal of this observational study is to systematically describe the clinical characteristics and outcomes of patients with pituitary complex and rare diseases at Peking Union Medical College Hospital. The main questions it aims to answer are: * What are the influencing factors and rates of remission? * What are the comorbidities associated with these diseases? * What are the perioperative events, radiological findings, and pathological features? Researchers will compare different patient groups to see if there are significant differences in these outcomes. Participants will: * Undergo detailed clinical evaluations. * Provide medical history and data for analysis. * Participate in follow-up assessments to monitor disease progression and treatment outcomes.
Detailed description
The study aims to provide a comprehensive analysis of pituitary complex and rare diseases at Peking Union Medical College Hospital. By leveraging a large cohort, the research will explore various clinical characteristics and outcomes. Specifically, the study will examine influencing factors and rates of remission, the presence of comorbidities, and perioperative events. Additionally, it will evaluate radiological findings and pathological features to better understand these conditions. Through this detailed investigation, the study seeks to enhance knowledge and inform clinical practice regarding the management and prognosis of pituitary complex and rare diseases.
Interventions
PROCEDURESurgical Removal
Resection of pituitary pathologies.
PROCEDUREBiopsy
Taking a small tissue or liquid sample from the pituitary pathologies and the affected area for examination and diagnosis
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Diagnosed with rare sellar diseases including but not limited to pituitary adenomas (such as Thyrotropin-secreting pituitary adenomas, GH-secreting adenomas), craniopharyngiomas, Rathke's cleft cysts, sellar region germ cell tumors, cavernous sinus syndrome, and other diseases * Detailed medical history, including clinical symptoms, treatment plans and follow-up outcomes
Exclusion criteria
* Incomplete medical records, especially missing key imaging diagnostic results * Patients with coexisting primary central nervous system diseases unrelated to sellar region diseases (such as severe traumatic brain injury) * Patients whose sellar region pathological diagnosis was changed or overturned during the follow-up period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Remission | Postoperative one week and extends to the latest follow-up, estimated at up to 3 years | Hormonal normalization and free of pathologies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease Comorbidities | From patient admission to an evaluation period extending up to the latest follow-up, estimately up to 3 years | Systemic changes accompanied with Pituitary Complex and Rare Diseases |
| Postoperative complications | Postoperative one week and extends to the latest follow-up, estimated at up to 3 years | adverse events or medical issues that arise after a surgical procedure on the pituitary diseases.These complications can include various problems such as bleeding, infection, hormonal imbalances, cerebrospinal fluid leaks, vision changes, or neurological deficits |
Countries
China
Contacts
Primary ContactYong Yao, MD
Outcome results
None listed