Arthritis Knee, Bariatric Surgery Candidate, Prosthesis Failure, Prosthesis-Related Infections, Prosthesis Survival
Conditions
Keywords
arthroplasty, revision, bariatric
Brief summary
Previous studies have investigated the outcomes of Knee Arthroplasty (KA) following Bariatric Surgery (BAS), but with substantial limitations as not stratifying for Body Mass Index (BMI) at time of KA or not addressing the type of BAS (gastric bypass, banding or sleeve). Since BMI varies greatly in patients with previous BAS, it is likely that BMI affects outcomes after KA in BAS-operated patients. The investigators believe that stratifying for BMI would explain the contradictions with the previous research in this patient group when it comes to the risk of revision after KA.
Interventions
OTHERBAS
NOMESCO (Nordic Medico-Statistical Committee) Classification of Surgical Procedures (KJDF10 \& KJDF11 \[gastric bypass\]; KJDF20 \& KJDF21 \[gastric banding\]; KJDF40, KJDF41, KJDF96 \& KJDF97 \[gastric sleeve\]).
OTHERNon-BAS
Patients without BAS codes
Sponsors
Bispebjerg Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Primary knee arthroplasty due to osteoarthritis
Exclusion criteria
* Primary knee arthroplasty due to traumatic osteoarthritis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hazard rate of Revision due to any cause | within 90 days and within 2 years | Revision surgery is defined as surgery with debridement and/or exchange of at least one component |
| Hazard rate of Revision due to infection | within 90 days and within 2 years | Our definition of infection is adapted from the European Bone and Joint Infection Society (EBJIS) criteria as at least one of the following A. An indication of deep infection is reported to the Danish knee arthroplasty register (DKR) by the surgeon on revision surgery B. At least 2 deep-tissue samples of phenotypically indistinguishable bacteria isolated from at least 3 deep-tissue samples C. One or more positive intraoperative samples from a closed fluid aspirate AND a biopsy (fluid AND tissue) of phenotypically indistinguishable bacteria isolated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hazard rate of Knee related antibiotic use within 30- and 90-days following KA | within 30- and 90-days following KA | the use of one of the following oral antibiotics: dicloxacillin, flucloxacillin, phenoxymethylpenicillin, amoxicillin, oral ciprofloxacin, roxithromycin, linezolid, cefuroxime and cefalexin |
| Hazard rate of Antibiotic use due to other causes | within 30- and 90-days following KA | the use of one of oral antibiotics other than those that were mentioned in outcome 3. |
| Mortality | 2 years postoperatively | Mortality registered in the Danish Civil Registration System (DCRS) by date |
Countries
Denmark
Contacts
STUDY_DIRECTORSøren Overgaard, MD,DMSc,Prof
Department of orthopedic surgery, Bispebjerg University Hospital, Denmark
Outcome results
None listed