Coagulation Factors Alterations, Platelet Activation, Thoraco-abdominal Aortic Aneurysm Repair
Conditions
Brief summary
This study will evaluate the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
Detailed description
Endovascular aneurysm repair of abdominal aorta activates a significant inflammation reaction and has an impact on coagulation. Platelet activation seems to have a major role in this prothrombotic and hypercoagulable state. In complex thoraco-abdominal aortic aneurysm repair the implants are more complexed and the duration of operation longer. The main hypothesis is that all the above have a greater impact on platelet activation and coagulation alterations. The aim of this study is the evaluation of the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
Interventions
OTHERPatients undergoing complex thoraco-abdominal aortic aneurysm repair
Patients undergoing complex thoraco-abdominal aortic aneurysm repair
Sponsors
University of Thessaly
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included.
Exclusion criteria
* Refuse to participate * Prior surgery within 3 months * ASA PS \> 3 * Known medical history of thrombophilia or functional platelet dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Coagulation status | Day of surgery, 1st postoperative day, 4-5th postoperative day | Early preoperatively, early and late postoperatively |
| Myocardial injury after non cardiac surgery | Day of surgery, 1st postoperative day, 4-5th postoperative day | Early preoperatively, early and late postoperatively |
| Acute kidney injury | Day of surgery, 1st postoperative day, 4-5th postoperative day | Early preoperatively, early and late postoperatively |
| Post-implantation syndrome | Day of surgery, 1st postoperative day, 4-5th postoperative day | Early preoperatively, early and late postoperatively |
| Major cardiovascular events | Day of surgery, 1st postoperative day, 4-5th postoperative day | Early preoperatively, early and late postoperatively |
| Major cardiovascular events, implant failure and death of any cause | 30 days, 3, 6, and 12 months postoperatively | Early preoperatively, early and late postoperatively and 1 at one month |
Countries
Greece
Contacts
CONTACTEleni Arnaoutoglou, Prof
CONTACTMaria Ntalouka
STUDY_CHAIREleni Arnaoutoglou, Prof
University of Thessaly
Outcome results
None listed