Hyaluronic Acid Delivery: CO2 Laser Versus Thulium Laser Treatment

In Vivo Visualisation of Hyaluronic Acid After CO2 Laser Compared to Thulium Laser Treatment

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06431282

Enrollment

Registered

2024-05-28

Start date

2024-02-20

Completion date

2024-06-30

Last updated

2024-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging Skin

Brief summary

* Weakly crossed-linked hyaluronic acid (HA) can be delivered through multiple injections into the dermal and subnormal layer to improve skin quality. However, this treatment comes with multiple bumps for several days. * Alternatively, HA can be delivered after CO2 laser or thulium laser pretreatment. As microscopic analysis after this treatment is limited, the object of the present study is to investigate the morphological cellular changes after CO2 laser and thulium laser delivered HA into human skin.

Interventions

OTHERCO2 laser + HA

Probands will be treated with a CO2 laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.

OTHERThulium laser + HA

Probands will be treated with a thulium laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

\- healthy male and female patients

Exclusion criteria

* pregnancy, breast feeding * open wounds at the area to be treated

Design outcomes

Primary

Measure	Time frame	Description
Size of hyaluronic acid granules	30 minutes and 30 days after treatment.	Size of HA granules after CO2 or thulium laser treatment compared to control.
Size of intercellular spaces	30 minutes and 30 days after treatment.	Size of intercellular spaces after CO2 or thulium laser treatment compared to control.
Size of keratinocytes	30 minutes and 30 days after treatment.	Size of keratinocytes after CO2 or thulium laser treatment compared to control.
Distribution of Hyaluronic Acid	30 minutes and 30 days after treatment.	Distribution though the epidermal and dermal layers after CO2 or thulium laser treatment compared to control.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026