Respiratory Distress Syndrome, Adult
Conditions
Brief summary
This study aims to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
Detailed description
Recent studies have shown that mechanical power (MP) values below 17 J/min and driving pressure (DP) values below 15 cmH2O reduce intensive care unit (ICU) mortality. Asar et al. have introduced six new oxygenation indices utilizing MP and DP instead of Pmean (OSI-MPtot, OI-MPtot, OSI-ΔPinsp, OI-ΔPinsp, OSI-MPdyn, OI-MPdyn). They compared the predictive abilities of these new indices for ICU mortality in Covid-ARDS (C-ARDS) patients with conventional oxygenation indices (P/F, SpO2/FiO2, OI, OSI, PaO2/(FiO2xPEEP), and SpO2/FiO2xPEEP). OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices exhibited the highest predictive power for ICU mortality. However, cut-off values for the diagnosis and severity determination (mild, moderate, and severe) of ARDS patients have not been investigated. In this study, our objective is to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
Interventions
None listed
Sponsors
SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi
Başakşehir Çam & Sakura City Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients admitted to intensive care units diagnosed with ARDS / C-ARDS according to the Berlin criteria. 2. Adult patients aged between 18 and 80 years
Exclusion criteria
1. Patients under the age of 18 2. Pregnant patients 3. Patients without ARDS 4. Patients with missing data 5. Patients transferred to another hospital 6. Patients discharged from the ICU within 72 hours 7. Patients receiving extracorporeal membrane oxygenation (ECMO) support. 8. Patients were on mechanical ventilation for less than 24 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenation indices | During 28 days in the intensive care unit | It was aimed to compare the oxygenation indexes of the patients. It will be examined which of these indices is more effective in diagnosing ARDS. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Other parameters | During 28 days in the intensive care unit | It was aimed to compare the sequential organ failure assessment scores of the patients. Score ranges from 0 (best outcome) to 24 (worst outcome) points. |
| acute physiology and chronic health evaluation-II | During 28 days in the intensive care unit | It was aimed to compare the acute physiology and chronic health evaluation-II scores of the patients. Score ranges from 0 (best outcome) to 71 (worst outcome) points. |
| Charlson comorbidity index scores | During 28 days in the intensive care unit | It was aimed to compare the Charlson comorbidity index scores of the patients. Based on the Charlson comorbidity index score, the severity of comorbidity was categorized into three grades: mild, with Charlson comorbidity index scores of 1-2; moderate, with Charlson comorbidity index scores of 3-4; and severe, with Charlson comorbidity index scores ≥5. |
| arterial blood gas parameters | During 28 days in the intensive care unit | It was aimed to compare the pH of the patients. |
Countries
Turkey (Türkiye)
Outcome results
None listed