Lupus Nephritis
Conditions
Brief summary
* To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis, and determine the factors associated with levels of T regs . * To compare the functional capacity of T regs in LN and in normal individuals.
Detailed description
Lupus Nephritis (LN) encompasses a group of glomerulonephrites, that occur in association with systemic lupus erythematosus (SLE). The mainstream theory that it is an immune disease resulting from loss of immune tolerance against body cells. The regulatory T cells (T regs ) are a subpopulation of immune cells that maintain tolerance to self-antigens and suppress autoimmune diseases. The main marker of Tregs is FoxP3 (forkhead box protein 3) positivity. Moreover, It has been suggested that functional capacity of Tregs is also compromised in autoimmune diseases. Studying the role of T regs in LN is a promising field that can help tailor current immune therapy and develop new treatment strategies.
Interventions
DIAGNOSTIC_TESTT-reg cells
laboratory test
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
adults both genders clinical diagnosis of lupus nephritis
Exclusion criteria
patients diagnosed with other renal pathologies, e.g. diabetic kidney disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FoxP3 between groups | baseline | mean difference of FoxP3 between groups. |
| Association of FoxP3 and activity index | baseline | correlation between level of FoxP3 and activity index in the group with active LN. |
| Tregs in normal and lupus participants | baseline | mean difference of suppression capacity of Tregs between normal participants and patients with active LN. |
Contacts
Primary ContactMohamed AH Hussein
Outcome results
None listed