Depression, Gingivitis, Inflammation, Inflammatory Response
Conditions
Brief summary
The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis. The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?
Detailed description
Background: The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease. The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1) and interleukin-1 beta (IL-1β) in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals. Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits. depression regardless of periodontal status.
Interventions
OTHERPeriodontal clinical measurements, Saliva sampling
Clinical periodontal indices; Probing depth, Clinical attachment level, bleeding on probing, gingival index, and plaque
Sponsors
Medipol University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 53 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who were moderate in severity according to the test result, who had not started drug therapy yet and who had not received antidepressant medication in the last 12 months
Exclusion criteria
Patients with * psychotic disorders * autism spectrum disorders * other anxiety disorders * bipolar disorder * mental any organic mental disorder and * smokers, substance users
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SalivaryTREM-1 | 06-09 2019 | Both, soluble and membrane-bound TREM-1, are detected by the TREM-1 ELISA. |
| Salivary PGLYRP1 | 06-09 2019 | Both, soluble and membrane-bound PGLYRP1 are detected by the PGLYRP1 ELISA. |
| Salivary IL-1β | 06-09 2019 | Both, soluble and membrane-bound IL-1β detected by the IL-1β ELISA. |
Countries
Turkey (Türkiye)
Outcome results
None listed