Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06426524

Enrollment

Registered

2024-05-23

Start date

2023-05-19

Completion date

2024-05-31

Last updated

2024-05-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intrabony Periodontal Defect

Brief summary

The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.

Detailed description

In test group, after reflection of flap and degranulation, IGF-1 gel with hydroxyapatite will be placed in the defect and sutures will be placed. In control group, after reflection of flap and degranulation, hydroxyapatite will be placed in the defect and sutures will be placed.

Interventions

PROCEDUREIGF-1 Gel

After degranulation of the defect, IGF-1 gel mixed with Hydroxyapatite graft will be placed in the defect.

PROCEDUREHydroxyapatite

After degranulation of the defect, Hydroxyapatite graft will be placed in the defect.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Systemically healthy male and female patients of age \>18 years Intrabony defects - two wall or three wall defects Probing pocket depths (PPD) of \>5mm.

Exclusion criteria

Medically compromised patients Pregnant women Heavy smokers Patients who underwent radiotherapy or chemotherapy are excluded

Design outcomes

Primary

Measure	Time frame	Description
Bone Regeneration	3 months and 6 months	Radiovisiography (RVG) will be used to assess bone regeneration achieved post operatively after 3 months and 6 months.
clinical attachment level	3 months and 6 months	Assessment of clinical attachment level using UNC-15 probe at baseline and post operatively at 3 and 6 months.
Probig depth	3 months and 6 months	Assessment of probing depth using UNC-15 probe at baseline and postoperatively at 3 and 6 months.

Secondary

Measure	Time frame	Description
Plaque Index	3 months and 6 months	Assessment of plaque (PI) - according to Turesky modification of Quigley and Hein Plaque Index, 1970.

Countries

India

Contacts

Primary ContactDr R Viswa Chandra, MDS;DNB;PhD

viswachandra@hotmail.com8179367147

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026