Cancer
Conditions
Brief summary
The goal of this clinical trial is to to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times in patient with oncologic pathology . The main question\[s\] it aims to answer are: * \[question 1\] * \[question 2\] Participants will \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items\].
Detailed description
Whole body hybrid PET/CT imaging, making use of the standardized uptake value (SUV), is well established in clinical setting for diagnosis and staging, treatment response monitoring and radiation therapy treatment planning of a wide range of oncologic malignancies. However, the SUV metric derived from static PET data does not capture the dynamics of the PET probe biodistribution in the body. The present work proposes to fill in this notable gap: namely to merge whole-body and dynamic PET/CT imaging, to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times. Our proposed approach has the potential to significantly enhance diagnostic, prognostic and treatment response monitoring capabilities of PET/CT and to fundamentally alter routine clinical practice.
Interventions
RADIATIONPET/CT with FDG or FES
The study consists of an additional 50 minutes of imaging during the radiotracer's uptake phase prior to their clinical scan (standard of care).
Sponsors
Valentina Garibotto
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
PET/CT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients clinically indicated for whole-body PET evaluation. 2. Patient must agree to lie still in the camera. 3. Patient must be able to comply with study procedures. 4. Patient must be able to provide informed consent.
Exclusion criteria
1. Patients \< 18 years of age. 2. Pregnant women are excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Standard SUV measurement metric | through study completion , an average of 2 years | The standard SUV measurement metric will be compared with the measured influx rate Ki as obtained from dynamic PET/CT imaging for FDG-avid processes. We expect a correlation coefficient of at least 0.8. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Image quality | through study completion , an average of 2 years | This will be assessed by clinical PET/CT readers, on a 5 point scale. |
| Certainty in diagnosis of FDG-avid processes | through study completion , an average of 2 years | This will be assessed by clinical PET/CT readers, on a 5 point scale. |
Countries
Switzerland
Contacts
Primary ContactValentina Garibotto, Pr
Backup ContactIsmini Mainta, Dr
Outcome results
None listed