Bipolar Disorder, Nonsuicidal Self Injury, Suicidal Ideation, Suicide, Attempted
Conditions
Keywords
Lithium, Bipolar disorder, Suicide, Nonsuicidal Self Injury
Brief summary
This study aims to use a retrospective cohort approach to explore the impact of lithium carbonate on suicide and self-harm related events among adolescents and young adults with bipolar disorder in China.The primary objective of this study is to investigate the effects of lithium carbonate on suicidal ideation in adolescents and young adults with bipolar disorder in China. Secondary objectives include exploring its effects on preventing suicide attempts, non-suicidal self-injury, and aggressive behaviors in this population.
Interventions
DRUGLithium Carbonate
Participants must have been prescribed lithium for the past year and demonstrate at least 80% adherence to their lithium medication regimen during the first six months of the study period.
DRUGNon-lithium medication
No history of lithium use within the past year
Sponsors
Jiangsu Nhwa Pharmaceutical Co., Ltd.
Peking University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
\- 1 For Lithium group 1. Aged 12-45 years (adolescents 12-17, young adults 18-45). 2. Diagnosed with bipolar disorder using the the Mini-International Neuropsychiatric Interview (M.I.N.I.) (M.I.N.I.; version 5.0) based on Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria. 3. Adolescents diagnosed using the M.I.N.I. Kid version. 4. Lithium medication adherence of at least 80% in the first six months over the past year. 5. Not in an acute phase of illness. 6. Patient or guardian able to participate in assessment interviews. 7. Informed consent signed by participants and guardians (for adolescents). 2 for Non-lithium group 1. Aged 12-45 years (adolescents 12-17, young adults 18-45). 2. Diagnosed with bipolar disorder using the Mini-International Neuropsychiatric Interview (M.I.N.I.; version 5.0) based on DSM-IV criteria. 3. Adolescents diagnosed using the M.I.N.I. Kid version. 4. No lithium use over the past year. 5. Not in an acute phase of illness. 6. Patient or guardian able to participate in assessment interviews. 7. Informed consent signed by participants and guardians (for adolescents).
Exclusion criteria
1. Severe physical illness or active substance abuse. 2. Severe cognitive impairments, including developmental delays or dementia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Suicidal ideation | over the past year | Measured using the Columbia Suicide Severity Rating Scale (C-SSRS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Suicidal attempt | over the past year | measured using the Columbia Suicide Severity Rating Scale (C-SSRS) |
| Non-suicidal self-injury | over the past year | — |
| Violent and aggressive behaviors | over the past year | measured using the Chinese version of the Buss & Perry Aggression Questionnaire |
Other
| Measure | Time frame | Description |
|---|---|---|
| Depressive symptoms | over the past two weeks | measured by Beck Depression Inventory |
| Mood symptoms | over the past year | measured by Mood Disorder Questionnaire |
Countries
China
Contacts
Primary ContactXin Yu
Backup ContactNi Xu
Outcome results
None listed