The Dual Impact of Cirrhosis on Transplantation for Hepatocellular Carcinoma：a Two-center Retrospective Cohort Study in China

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06420791

Enrollment

Registered

2024-05-20

Start date

2024-02-28

Completion date

2024-05-06

Last updated

2024-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis, Hepatocellular Carcinoma

Brief summary

Background: This study aims to investigate the correlation between cirrhosis and hepatocellular carcinoma (HCC) recurrence after Liver Transplantation. Methods: The study retrospectively collected data enrolled from 519 HCC patients who underwent liver transplantation from two center(the First Affiliated Hospital, Zhejiang University School of Medicine and Shulan (Hangzhou) Hospital, January 2015 to December 2020), Based on important variables, 1:3 propensity score matching (PSM) were performed respectively.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

The patients undergoing liver transplantation for HCC from January 2015 to December 2020.

Exclusion criteria

Re-transplantation or combined liver-kidney transplantation; incomplete laboratory or clinical data; death within 90 days.

Design outcomes

Primary

Measure	Time frame
The overall survival rate was evaluated by follow-up investigation and outpatient review	2-5 years

Secondary

Measure	Time frame
The tumor-free survival rate was evaluated by follow-up investigation and outpatient review	2-5 years

Countries

China

Outcome results