Medication-Related Osteonecrosis of Jaw
Conditions
Brief summary
This study aims to conduct a detailed analysis of the immunological response profiles that emerge at different clinical stages of medication-related osteonecrosis of the jaw (MRONJ). The research seeks to understand how these responses influence the pathogenesis, staging, and treatment of MRONJ. Throughout the study, cytokine levels, inflammation markers, and other immunological parameters observed at various stages will be comprehensively assessed. The results of these analyses are expected to provide insights into how stage-specific immunological variables could play a role in the diagnosis and treatment of MRONJ.
Interventions
None listed
Sponsors
Marmara University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Individuals aged 18 and over * Both male and female participants * Individuals who apply to the Oral and Maxillofacial Surgery Clinic at Marmara University Faculty of Dentistry due to medication-related osteonecrosis of the jaw during the study period * Individuals or their legal representatives who have provided written consent to participate in the study
Exclusion criteria
* Non-drug-related osteonecrosis/osteomyelitis * Osteoradionecrosis * Metastasis to the oral region * Individuals who have not given written consent to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lymphocyte Proliferation Analysis | Baseline | This outcome evaluates the proliferation capacity of peripheral blood mononuclear cells (PBMCs) isolated from the study participants. This analysis will help quantify and understand the dynamics of lymphocyte activation and proliferation in response to different clinical stages of MRONJ and potentially identify immunological differences that could inform therapeutic strategies. |
| Apoptosis Analysis in Lymphocytes | Baseline | This outcome assesses apoptosis in lymphocytes isolated from the peripheral blood of participants included in the study. This analysis aims to quantify apoptotic processes in lymphocytes, offering insights into cell death mechanisms under varying conditions of culture and potentially relating these mechanisms to the immunopathology of MRONJ. |
| Cytokine Profile Analysis | Baseline | This outcome measures the levels of specific cytokines as indicators of immunological response in MRONJ at different disease stages. The cytokines to be analyzed include IL-17, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactFerit Bayram, PhD
Outcome results
None listed