Liver Transplant Recipients
Conditions
Brief summary
Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea, vomiting in the postoperative period. Propofol also has antioxidant properties. Because of its antioxidant properties propofol may have a protective effect against oxidative stress and ischemia reperfusion injury in major organs during liver transplant surgery. However, there are no studies showing the effect of isoflurane and propofol on Intraoperative hemodynamics and postoperative liver and kidney functions.Thus, we are conducting this study to know the effect of these agents on intraoperative hemodynamics and postoperative liver and kidney function.
Interventions
DRUGTarget control infusion propofol
target control infusion of propofol for target plasma concentration 2.5mcg/ml and BIS 40-60
Inhalational Isoflurane at concentration 1-2%
Sponsors
Institute of Liver and Biliary Sciences
Institute of Liver and Biliary Sciences, India
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Randomised, controlled, double blind
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
-Above 18 years of age who will undergo living donor liver transplant \-
Exclusion criteria
Refusal to consent * Acute liver failure, Acute on chronic liver failure * Allergic to propofol or any component of propofol * Patients with pre existing cardiac dysfunction and cardiomyopathy * Patients with pre existing renal dysfunction/ deranged RFTs preoperatively
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of total Noradrenaline and vasopressin requirement between isoflurane and TCI propofol group in Living donor liver transplant recipients intraoperatively. | INTRAOPERATIVELY | TCI propofol will provide more stable hemodynamics |
Secondary
| Measure | Time frame |
|---|---|
| To compare between the two groups mean systemic vascular resistance during different phases of liver transplant recorded every 15 minutes | INTRAOPERATIVELY AT 15 MINUTES INTERVAL |
| To compare between the two groups cardiac output during different phases of liver transplant recorded every 15 minutes | INTRAOPERATIVELY AT 15 MINUTES INTERVAL |
| Total vasopressor requirement during reperfusion | Intraoperative |
| Peak dose of nordrenaline and vasopressin during different phases of liver transplant intraoperatively | Intraoperatively |
| QTc interval between the two groups during different phases of liver transplant measured every 15 minutes | Intraoperatively every 15 mins |
| Peak lactate levels intraoperatively | Intraoperatively |
| To compare between the two groups mean arterial pressure during different phases of liver transplant recorded every 15 minutes | INTRAOPERATIVELY AT 15 MINUTES INTERVAL |
| Postoperative Liver function tests ie AST and ALT | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative Liver function tests ie GGT | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative Liver function tests ie platelet count | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative coagulation profile | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative Renal function tests i.e. Blood urea and S.creatinine levels | at12, 24, 72 hours and day7 postoperatively |
| Postoperative Liver function tests ie Bilirubin and albumin | at 12, 24, 72 hours and day 7 postoperatively |
Countries
India
Contacts
Primary ContactAbhinav Sharma, MD
Outcome results
None listed