End Stage Liver Disease, Hepatocellular Carcinoma
Conditions
Keywords
Liver Transplantation, Hypothermic Oxygenated Machine Perfusion
Brief summary
In this observational cohort study data on all patients undergoing liver transplantation after hypothermic oxygenated machine perfusion at Medical University of Vienna will be prospectively recorded. Investigation of short- and long-term outcome in this cohort will be conducted.
Interventions
None listed
Sponsors
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients undergoing liver transplantation with the use of hypothermic oxygenated machine perfusion * age ≥ 18 years
Exclusion criteria
* pregnancy * partial grafts * the anatomical integrity of the liver is not preserved in a way that makes the perfusion of the liver possible
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of ischemic-type biliary lesions | Within one year after liver transplantation | Non-anastomotic stenosis, post-transplant cholangiopathy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of early allograft dysfunction | Evaluated within the first 7 postoperative days | Deviation of bilirubin, transaminases or international normalised ratio |
| Rate of primary non-function | Evaluated in the immediate postoperative period, specifically within the first postoperative week | — |
| Incidence of re-transplantation | Evaluated in the immediate postoperative period, specifically within the first postoperative week | — |
Countries
Austria
Contacts
Primary ContactDavid Pereyra, MD, PhD
Backup ContactJule Dingfelder, MD
Outcome results
None listed