Aging, Hypoxia, Menopause, Vasodilation
Conditions
Brief summary
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
Interventions
DRUGPlacebo
Participants will receive a placebo in pill form.
DRUGPropranolol
Participants will receive oral propranolol (1 mg/kg).
DRUGGemtesa
Participants will receive oral gemtesa (75 mg).
Sponsors
University of Missouri-Columbia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Female assigned at birth * Pre, peri- or post-menopausal * Healthy weight (BMI ≥18 and ≤30 kg/m2)
Exclusion criteria
* Male (assigned at birth) * Pregnancy, breastfeeding * Use of hormone replacement therapies * Hysterectomy * Body mass index \>30 kg/m2 * Diagnosed sleep apnea * Current smoking/Nicotine/Drug use * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications * Malignant cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Forearm blood flow | Change from baseline to 5 minutes. | Blood flow in the forearm measured with venous occlusion plethysmography. |
Countries
United States
Contacts
CONTACTJacqueline Limberg
Outcome results
None listed