Caffeine, Infant,Premature
Conditions
Brief summary
This study investigates how brain activity and breathing changes in premature babies when their dose of caffeine treatment is changed or stopped. The study will assess premature babies receiving caffeine treatment as part of their clinical care. Brain activity will be recorded just before caffeine dose is changed and again two days afterwards. Breathing and other 'vital signs' (breathing rate, heart rate, oxygen saturation) will be recorded from the baby's monitor between the recordings of brain activity and for up to two weeks afterwards.
Interventions
DRUGCaffeine
We will record infant's brain activity and vital signs when caffeine dose is changed or caffeine treatment is stopped. The decision to change dose/stop treatment will be made by the clinical team as part of routine care. No changes in caffeine treatment will be carried out solely for research purposes.
Sponsors
University of Oxford
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 37 Weeks
Healthy volunteers
No
Inclusion criteria
* Born to a mother aged 16 or over * Admitted to the Newborn Care Unit, John Radcliffe Hospital * Born prematurely (before 37 weeks' gestation) * Parent given informed written consent * Receiving caffeine citrate
Exclusion criteria
* Known chromosomal abnormality or life-threatening congenital abnormality * Severe hypoxic insult at birth * Intraventricular haemorrhage grade III or IV or other severe neurological pathology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiration | From baseline to two days later | Change in respiratory dynamics between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later |
| Brain activity | From baseline to two days later | Change in EEG activity between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | From baseline to two days later | Change in heart rate between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later |
| Oxygen saturation | From baseline to two days later | Change in oxygen saturation between baseline (time at which caffeine dose is changed/treatment ends) and approximately 2 days later |
Countries
United Kingdom
Contacts
Primary ContactCaroline Hartley
Outcome results
None listed