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Tapse/Pasp General Anesthesia

Prediction of TAPSE/PASP Ratio for Hypotension Due to General Anesthesia Induction

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06414811
Enrollment
52
Registered
2024-05-16
Start date
2024-05-15
Completion date
2025-03-15
Last updated
2024-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension

Keywords

TAPSE, PASP, GENERAL ANESTHESİA

Brief summary

TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function. TAPSE/PASP can be calculated as load-independent parameters to evaluate RV function. Because RV function is sensitive to change in afterload, known as the RV-pulmonary circulation (PC) connection. This study aims to identify patients who are candidates for hypotensive events due to general anesthesia in a hemodynamically stable population.

Detailed description

TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function. TAPSE/PASP can be calculated as load-independent parameters to evaluate RV function. Because RV function is sensitive to change in afterload, known as the RV-pulmonary circulation (PC) connection. This study aims to identify patients who are candidates for hypotensive events due to general anesthesia in a hemodynamically stable population. Patients will be measured by transthoracic echocardiography in the preoperative period, 15-30 minutes before induction. Basal hemodynamic parameters and non-invasive and/or hemodynamic values will be recorded every two minutes after induction until surgical incision.Patients with a 30% decrease in SBP from the baseline and a decrease in MAP below 65 mmHg in the first 10 minutes after anesthesia induction will be considered to have hypotension. Patients will be divided into 2 groups: 'with' and 'without' hypotension.

Interventions

OTHERHYPOTENSİON

MAP below 55 mmHg or long-term (2 minutes or more) hypotensive attacks will be treated with ephedrine 0.1mg/kg.

Sponsors

Aydin Adnan Menderes University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years

Inclusion criteria

1. Written informed consent; 2. 18-75 years old 3. ASA Physical Status 1-3; 4. Patients planned for surgery

Exclusion criteria

1. The patient is pregnant 2. After cardiac surgery 3. Severe pulmonary hypertension 4. Severe valve disease 5. Hypertrophic or dilated cardiomyopathy 6. Presence of acute myocardial infarction 7. Patients with severe visual or hearing impairment/disability 8. ASA physical status IV or V 9. Ischemic heart disease, conduction disorder.

Design outcomes

Primary

MeasureTime frameDescription
1. tension4-5 hours]Intraoperative systolic arterial tension, diastolic arterial tension and mean arterial tension will be taken and recorded for the patients.

Countries

Turkey (Türkiye)

Contacts

Primary Contactferdi gülaştı
ferdigulasti@gmail.com+905054929650

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026