Dehydration
Conditions
Brief summary
It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin. The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.
Interventions
OTHERPlain Water
Plain water without calories, sweetener, or electolytes
Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV
OTHERLiquid IV Sugar Free
10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV
Sponsors
Arizona State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Masking description
non labeled bottles
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-60 years * Training at least 2 times per week * stable weight for the last 2 months (fluctuation less than 5 pounds)
Exclusion criteria
* Night shifting work * Thyroid medication * Bariatric surgery * Cardiovascular disease * Renal disease * Hepatic disease * Participating in another study at the same time * Bodyweight over 110 pounds
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total fluid intake | 4 hours of rehydration | Total amount of fluid ingested |
| Net fluid balance | at 4 hours of the rehydration period | amount of water retained during the rehydration period |
| Rate of absorption | during the first 30 minutes of rehydration | The rate of Deuterium appearance in the blood during 30 minutes of rehydration |
| Cumulative urine output | during the first 3 hours of rehydration | Total amount of urine output during rehydration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thirst | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period | Thirst estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception |
| Plasma copeptin | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period | Plasam Copeptin during rehydration |
| Taste Likeness | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period | Taste Likeness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception |
| Stomach fullness | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period | Stomach fullness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception |
| Plasma volume | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period | percent of plasma volume recovery during the rehydration |
| Free water Clearance | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period | Free water clearance calculated based on plasma and urine osmolality |
| Free Osmotic Clearance | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period | Free Osmotic clearance calculated based on plasma and urine osmolality |
Countries
United States
Outcome results
None listed