Effect of Drug
Conditions
Keywords
Afentanil, sufentanil, bronchoscopy, Recovery time
Brief summary
The equivalent dose of sufentanil and afentanil combined with laryngeal mask was used for complex bronchoscopy to observe the intraoperative effect and the influence on the recovery of patients
Detailed description
Afentanil is a powerful, fast-acting narcotic analgesic, which can effectively inhibit intubation reflex. Compared with sufentanil, it has a short half-life and is safer, and can be used as the first choice for short surgical analgesics. In this study, by comparing the use of equivalent dose sufentanil and afentanil combined with laryngeal mask for complex bronchoscopy, the intraoperative analgesic effect and the influence on the recovery of patients were observed, and a better anesthesia scheme was provided for tracheoscopy.
Interventions
DRUGAlfentanil
alfentanil 10ug/kg is used for anesthesia induction
Sponsors
Xinxiang Central Hospital
Tongji Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-80, * ASA I-III level; * BMI 18.5\ 23.9;
Exclusion criteria
* Patients with full stomach and high risk of reflux aspiration; * Allergic to benzodiazepines, opioids, rocuronium bromide; * Those who have taken sedative, analgesic or antidepressant drugs within 24 hours; * Pregnant and lactating women; * severe liver and kidney dysfunction; * Patients with severe anemia and hypoproteinemia; * Previous drug use history; * Recently participated in other clinical studies; * Patients who cannot cooperate with communication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| time of Recovery | 1day | the time from the end of surgery to awake of patient |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time records | 1 day | Anesthesia time, induction time, surgical time, awakening time and recovery time |
| dose of drugs | 1 day | The total amount of sedative and analgesic drugs used. |
| rate of respiratory suppression incidence | 1 day | Respiratory frequency\<8 times/min or SP02\<90% |
| rate of Incidence of Treatment-Emergent Adverse Events | 1day | Intraoperative blood pressure and heart rate changes: record the patient's intraoperative blood pressure, heart rate, and the use of related vasoactive drugs; Postoperative adverse reactions: such as hypertension, hypotension, tachycardia, gastrointestinal symptoms, postoperative restlessness, etc |
Other
| Measure | Time frame | Description |
|---|---|---|
| rate of Postoperative adverse reaction | 1 day | Airway obstruction, hypoxemia, apnea, laryngeal spasm, bronchospasm, cough, postoperative nausea and vomiting, postoperative pain (VAS score), hypotension, bradycardia, dizziness |
Countries
China
Outcome results
None listed