Vitiligo
Conditions
Brief summary
The present study will aim to evaluate: 1. The presence of Hypoxia Inducible Factor in vitiligo patient 2. Defect of Autophagy Related Genes in vitiligo patient 3. The cross relation between Autophagy Related Genes and Hypoxia Inducible Factor in the pathogenesis of vitiligo among Egyptian patients in Sohag Governorate
Interventions
DEVICEPunch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Adult \>18 years * With non segmental vitiligo * A group of participants will be included as a control group
Exclusion criteria
* Pregnancy * Patient with chronic inflammatory skin disorders * patient on anti-oxidant or anti-inflammatory drugs * patient on topical or systemic treatment for vitiligo in last 4 weeks * patients with other autoimmune diseases * patients with diabetes mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of Autophagy Related genes in Vitiligo patients | 2 months | Assess Autophagy Related genes levels in skin biopsy of vitiligo patient |
| Assessment of Hypoxia Inducible Factor in Vitiligo patients | 2 months | Assess level of Hypoxia Inducible factor in skin biopsy of vitiligo patient |
Countries
Egypt
Contacts
Primary ContactRania H Metwally, Resident
Backup ContactReham E El-Sharkawy, Professor
Outcome results
None listed