Perioperative Management & Outcome Following Preoperative Transthoracic Echocardiography in Noncardiac Surgery Patients

EuPreCHO: European Study on Perioperative Management and Outcome Following Preoperative Transthoracic Echocardiography in Noncardiac Surgery Patients

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06409234

Enrollment

8250

Registered

2024-05-10

Start date

2024-06-30

Completion date

2026-12-31

Last updated

2024-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective Surgical Procedure

Keywords

transthoracic echocardiography

Brief summary

In August 2022 the European Society of Cardiology published updated guidelines including recommendations on preoperative transthoracic echocardiography. The update resulted in broadened criteria for preoperative transthoracic echocardiography. The impact of preoperative transthoracic echocardiography on outcome is controversial and the evidence was mostly derived from administrative databases. Also there is also a knowledge gap in terms of what changes in perioperative managements are derived from transthoracic echocardiography information in current daily practice in Europe and what their impact on outcome may be. Further, a secondary analysis in a large international cohort suggests that the criteria endorsed by the guidelines to define the class of recommendation of transthoracic echocardiography may not be efficient.

Detailed description

The target population consists of patients at elevated cardiovascular risk undergoing elective, intermediate or high-risk noncardiac surgery. The planned sample size is 5500 exposed and 2750 non-exposed

Interventions

OTHERTransthoracic Echocardiography Recieved

Transthoracic Echocardiography Recieved

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* aged ≥65 years OR * above 18 years and presenting ≥2 cardiovascular risk factors (hypertension, smoking, dyslipidaemia, diabetes, family history of CVD) OR * above 18 years with known cardiovascular disease

Exclusion criteria

* under 18 years of age * day surgery * urgent/emergency procedures * current ICU patient (i.e. in ICU on day-1 or the day of the index surgery (day 0)), * cardiac surgery within the last month prior according to the index noncardiac procedure (of note this does not include cardiological interventions like TAVI or valvuloplasty), * unwilling or unable to provide informed consent, * unable to complete the WHODAS questionnaire (literacy or language barrier) * Previous enrollment in EuPreCHO (in case of repeated surgery)

Design outcomes

Primary

Measure	Time frame	Description
Major Pathology	30 days	Decreased contractility (LVEF ≤40% by Simpson's method or eyeballing) or based on corresponding qualitative statement in TTE report. Significant LV diastoic: E/A \<0.8 + E\>50cm/sec OR E/A \>0.8 to \<2 + at least ≥ 2 additional criteria ( Average E/e' ratio \>14, peak TR velocity \>2,8 m/sec, LA volume index \>34 mL/m2.

Secondary

Measure	Time frame	Description
Disability-free survival at 30 days	30 days	WHODAS scale-none=0 to extreme=4, for a total maximal score of 48 and transformed into the percentage of maximal disability score

Countries

Germany

Contacts

Primary ContactSaman Sepehr

saman.sepehr@esaic.org3222273999

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026