Cognition
Conditions
Keywords
Electrodes, Implanted, higher cognitive function, single neural activity
Brief summary
This study aims to investigate that neural activity of higher cognitve function of human brain with hyperflexible neural electrode-cortex
Detailed description
In this study, patients who need intracerebral puncture and indwelling drainage tube, such as intracerebral hemorrhage and hydrocephalus, will be recruited. Before implanting electrodes, patients will be trained to do higher cognitive function tasks.During operation, electrode will be implanted accompanied by placing drainage tube. After operation, patients will perform tasks, while electrophysiological signals will be collected. At the end of study, electrode will be removed.
Interventions
None listed
Sponsors
Chinese Academy of Sciences
Huashan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Inclusion criteria
1. aged 18-70 years old. 2. have selective or confine operation indications:spontaneous basal ganglia hemorrhage or lobar hemorrhage that need catheter aspiration and drainage;hydrocephalus that need V-P shunt; need placing ommaya. 3. GCS score 12-15; must be able to communicate with investigators in Mandarin and comply with study requirements. 4. volunteered to participate in this study and sign informed consent.
Exclusion criteria
1. have severe cognitive dysfunction. 2. have psychiatric disorders, such as depression, anxiety disorders and schizophrenia. 3. long-term use of special medications, such as hormones, immunosuppressant, and anticoagulants. 4. be allergic to surgery instruments or medications. 5. have general anesthesia, surgery contraindications. 6. have acute cardiac infarction or heart arrest within 6 months. 7. have other neurosurgery contraindications assessed by investigators. 8. lactation or pregnancy. 9. have serious systemic disease or organ dysfunctions that affects study outcome or visits. 10. participate in other ongoing clinical trials.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| recording local field potentiation | through study completion, an average of 2 year | The mechanism of higher cognitive functions will be investigated by analysing characteristics of local field potentiation which is correlated with higher cognitive functions tasks, such as events related potential, information coding, etc. |
| recording single neural spikes | through study completion, an average of 2 year | The mechanism of higher cognitive functions will be investigated by analysing characteristics of single neural spikes which is correlated with higher cognitive functions tasks, such as firing frequency, events related potential, information coding, etc. |
Countries
China
Contacts
Primary ContactXuehai Wu, Ph.D.
Outcome results
None listed