Active Tuberculosis, Latent Tuberculosis
Conditions
Keywords
Active Tuberculosis, LAtent Tuberculosis infection, Interferon-Gamma Release Assay, Quantiferon, Chest CT scan, Chest X-ray
Brief summary
The study is an evaluation of the diagnostic performance of different tests and their association in order to confirm or exclude active tuberculosis.
Detailed description
Background : diagnostic methods to distinguish between latent TB infection (LTBI) and active TB disease remains challenging. Data are scarce concerning the positive predictive value of Current diagnostic approaches, including Interferon-Gamma Release Assay (IGRA) and chest radiography, which is often very low. Computed tomography (CT) scanning, although not recommended by the World Health Organization (WHO) for TB diagnosis, may be of high interest in our high-income low-burden countries. This study assess the performance of the combination of CT scanning and IGRA to diagnose active pulmonary TB and identifies discriminatory CT scan features indicative of active disease. Methods : A retrospective study was conducted on 580 patients clinically suspected of TB or in contact with bacteriologically confirmed cases (index cases). Patients underwent IGRA testing, thoracic CT scans, and respiratory (or other organs) samples culture. CT scan findings were blindly analyzed, and a composite score combining significant radiological signs with IGRA results was constructed. Diagnostic performance measures, including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), were calculated.
Interventions
None listed
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Major patients who received the following examinations at the Montpellier University Hospital for tuberculosis screening (clinical suspicion and/or contact with a person with active tuberculosis): * Chest X-ray AND * Chest CT scan AND * Mycobacteriology examination of respiratory or tissue sample (direct/culture/GenXpert) AND * IGRA test (Quantiferon)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic performance (sensitivity) of the combination of IGRA and Chest CT scan | Over 12 weeks from the initial medical contact due to suspected tuberculosis to the confirmation or exclusion of this diagnosis | Sensitivity |
| Diagnostic performance (specificity) of the combination of IGRA and Chest CT scan | Over 12 weeks from the initial medical contact due to suspected tuberculosis to the confirmation or exclusion of this diagnosis | specificity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Positive Predictive value of the combination of IGRA and Chest CT scan | Over 12 weeks from the initial medical contact due to suspected tuberculosis to the confirmation or exclusion of this diagnosis | Positive Predictive value |
| Negative Predictive value of the combination of IGRA and Chest CT scan | Over 12 weeks from the initial medical contact due to suspected tuberculosis to the confirmation or exclusion of this diagnosis | Negative Predictive value |
Countries
France
Outcome results
None listed