Effects of Volume and Pressure-Controlled Ventilation on Cerebral SpO2, PI, and PVI Index in Septoplasty

Evaluation of the Effects of Volume-Controlled and Pressure-Controlled Ventilation on Cerebral Oxygen Saturation, Perfusion Index, and Pleth Variability Index in Septoplasty Surgical Cases: an Observational Prospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06407362

Enrollment

Registered

2024-05-09

Start date

2021-05-15

Completion date

2023-01-15

Last updated

2024-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perfusion Index, Pleth Variability Index, Regional Cerebral Oxygen Saturation, Ventilation Mode

Brief summary

Objective: This study was designed to evaluate the accuracy of Pleth Variability Index (PVI), Perfusion Index (PI) and Regional Oxygen Saturation (rSO2) in both ventilation modes in patients undergoing septorhinoplasty operation under general anaesthesia. Materials and Methods: After anaesthesia induction, ventilation was provided with volume control for 20 minutes. Heart Rate (HR), PI, PVI, Oxygen Saturation (SpO2), Non-Invasive Blood Pressure (NIBP) and rSO2 values were recorded every 5 minutes. At the 20th minute of the surgical procedure, the ventilation mode was set as the pressure-controlled mode. After switching to pressure-controlled mode, HR, PI, PVI, SpO2, NIBP and rSO2 values were recorded every 5 minutes for 20 minutes.

Interventions

DIAGNOSTIC_TESTCerebral Oxygen Saturation

We have designed this study to evaluate the accuracy of PVI, PI and rSO2 in both ventilation modes in patients undergoing septorhinoplasty operation under general anaesthesia

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* patients with American Society of Anesthesiologists (ASA) score I-III between the ages of 18-80 were included

Exclusion criteria

* Those patients with any Liver and/or Kidney Failure * obese patients (Body Mass Index (BMI) 30 and above) * trauma patients * cancer patients * ASA IV patients * those patients with emergency surgery * cardiac arrhythmia * implanted pacemakers * those with a history of chronic pain

Design outcomes

Primary

Measure	Time frame	Description
Pleth Variability Index (PVI) in patients under different ventilation modes	while the surgery procedure	The objective of this study was to demonstrate the percentage difference in the Pleth Variability Index (PVI) between the two ventilation modes in patients undergoing septorhinoplasty.
Perfusion Index (PI) in patients under different ventilation modes	while the surgery procedure	The objective of this study was to demonstrate the percentage difference in the Perfusion Index (PI) between the two ventilation modes in patients undergoing septorhinoplasty.
Regional Cerebral Oxygen Saturation (rSO2) in patients under different ventilation modes	while the surgery procedure	The objective of this study was to demonstrate the percentage difference in the Regional Cerebral Oxygen Saturation (rSO2) between the two ventilation modes in patients undergoing septorhinoplasty.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026