Adverse Birth Outcomes, Adverse Cardiac Event, Atherosclerosis, Cardiovascular Diseases, Pregnancy Complications
Conditions
Keywords
Atherosclerotic cardiovascular disease, Major adverse cardiac and cerebrovascular event, Adverse pregnancy outcome, Adverse birth outcomes
Brief summary
A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.
Detailed description
the current study aimed to evaluate the associations between maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes, and the combined effect of maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes on the risk of long-term adverse events of offspring.
Interventions
OTHERPre-existing atherosclerotic cardiovascular disease
Presence of pre-existing atherosclerotic cardiovascular disease
Sponsors
Samsung Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Inclusion criteria
* Women with live birth from Korea (between January 1, 2005 to December 31, 2019)
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurence of post-partum MACCE | up to 5 years | major adverse cardiac and cerebrovascular event |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurence of myocardial infarction | up to 5 years | Myocarrdial infarction |
| Occurence of revascularization | up to 5 years | percutaneous coronary intervention or coronary artery bypass grafting |
| Occurence of stroke | up to 5 years | Ischemic or hemorrhagic stroke |
| Occurence of adverse pregnancy outcome | At delivery | preterm delivery, pre-eclampsia or eclampsia, other hypertensive disorder of pregnancy, small-for-gestational-age, and gestational diabetes |
| Occurence of All-cause death | up to 5 years | Death from any causes |
| Occurence of neonatal adverse events in offspring | within 30 days | transient tachypnea, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, bronchopulmonary dysplasia, and sepsis |
| Occurence of adverse infant events in offspring | Within 1 year | admission to intensive care unit and occurrence of seizure events |
| Occurence of neurodevelopmental disorders | up to 5 years | autism spectrum disorder, attention-deficit/hyperactivity syndrome, cerebral palsy, any developmental delay including motor or cognitive delay, epileptic and febrile seizures and tics, and stereotypic behavior |
| Occurence of major congenital malformation in offspring | At delivery | congenital malformation in offspring |
Countries
South Korea
Contacts
Primary ContactKi Hong Choi
Backup ContactDanbee Kang, PhD
Outcome results
None listed