Skip to content

Retroclavicular Block in Vascular Surgey

Efficacy of Retroclavicular Dexamethasone With Bupivacaine in Patients Undergoing Upper Limb Vascular Surgeries

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06406712
Enrollment
80
Registered
2024-05-09
Start date
2024-06-01
Completion date
2026-12-01
Last updated
2026-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain Management

Brief summary

The retroclavicular (coracoid) approach for brachial plexus anesthesia is recognized for its facility and simplicity to perform . The block has been well described in the anesthesia community since it was first introduced by Hebbard and Royse in 2007 . In 2017, Luftig . first described the block's use in the ED setting for a variety of indications . Because of its different needle entry point, the retro clavicular (RCB) approach offers an almost perpendicular needle-ultrasound (US) beam angle.

Detailed description

Regional anesthesia (RA) offers several advantages over general anesthesia (GA) for upper limb orthopedic surgery. One of the advantages is the improvement in postoperative pain, which leads to decreased use of postoperative opioids needs and reduces the recovery time for patients . A variety of approaches for regional blockade for upper extremity surgery have been described. Dexamethasone is a corticosteroid drug that has been used as an adjuvant to reduce postoperative pain. The use of peri neural dexamethasone (i.e. dexamethasone added to the local anesthesia solution) as an adjuvant to peripheral nerve block to improve analgesia provided by local anesthetic alone . Peri neural dexamethasone, as an adjuvant to peripheral nerve block, has been associated with faster onset of anesthesia , longer duration of anesthesia/analgesia decreased postoperative pain intensity and decreased postoperative analgesia requirements compared with local anaesthetic alone . The exact mechanism by which dexamethasone reduces pain is not known. The decrease in pain intensity and the prolonged analgesia attained with the use of perineural dexamethasone may be the result of a local, or systemic action, or both . Dexamethasone may act locally on glucocorticosteroid receptors to induce vasoconstriction, thereby decreasing systemic absorption of local anaesthetics . Other potential mechanisms of action include suppression of C-fibre transmission of pain signals and direct action on the nerve cell to reduce neural discharge . Dexamethasone may act systemically by reducing the inflammatory response caused by surgical tissue injury .

Interventions

regional anesthesia

Sponsors

New Valley University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Patients undergoing upper limb vascular surgey .

Exclusion criteria

* \- Contraindications to regional block (coagulopathy, infection at the needle insertion site, or diaphragmatic paralysis). * Altered conscious level. * Pregnancy. * Body mass index (BMI \> 35). * Patients who have difficulty understanding the study protocol. * Patients who have any known contraindication to study medications. * Patient refusal.

Design outcomes

Primary

MeasureTime frameDescription
sensory and motor duration of block24 hoursefficacy of block

Countries

Egypt

Contacts

CONTACTahmed ismail, lecture
ahmed_ismail87@med.nvu.edu.eg01097845491
PRINCIPAL_INVESTIGATORahmed ismail, lecture

faculty of medicine , new valley university

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 8, 2026