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Risk of Malignancy in Endemic Long Standing Nodular Goitres: a Prospective Cohort Study

Risk of Malignancy in Endemic Long Standing Nodular Goitres: a Prospective Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06405919
Enrollment
160
Registered
2024-05-09
Start date
2017-03-01
Completion date
2018-09-30
Last updated
2024-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Incidence of Thyroid Cancer in Long Standing MNG

Keywords

: goitre, long standing, malignant risk, incidental.

Brief summary

To determine the incidence of thyroid cancer in patients with long standing goitres presenting for surgery.

Detailed description

This is a prospective cohort study The objective is to determine the incidence of cancer in patients with long standing goitres( more than 10 years ) who present for surgery in Khartoum Teaching Hopspital - Sudan. Introduction: goitre is endemic in Sudan with prevalence ranging between 5-42% in different regions of the country. Patients are referred for surgery only if they develop pressure symptoms. The incidence of thyroid carcinoma is high in endemic goitrous areas. Determining the risk of cancer in patient with long standing goitres may help in early early referral and early surgical intervention. Methods: This is prospective cohort study including 160 patients with long standing goitrers of 10 years or more who presented from March 2017 to September 2017 to Khartoum Teaching Hospital-Sudan

Interventions

DIAGNOSTIC_TESTHistopathology

Thyroidectomy for patients and histological examination of specimen to determine incidence of malignancy.

Sponsors

Sudan Medical Specialization Board
CollaboratorOTHER_GOV
University of Khartoum
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* All patients with long standing goitres of 10 years or more

Exclusion criteria

* Non

Design outcomes

Primary

MeasureTime frameDescription
Rate of malignancyMarch 2017-September 2018Rate of malignancy in resected goitre specimens

Countries

Sudan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026