Lung Cancer, Nonsmall Cell
Conditions
Keywords
non-small cell lung cancer, surgical margin, DFS, radiomics
Brief summary
The investigators retrospectively collected the participants with T3 and T4, N0-2, M0 NSCLC patients resected between January 2013 to December 2021 for training and internal validation. The Clinical data, preoperative laboratory results and images were collected. High-risk margins were defined as R1 or R2 surgical margins or local recurrence during follow-up, and the investigators also collected the disease-free survival time. On the Deepwise multi-modal research platform, the images were semi-automatically segmented and expanded outward by 3mm to obtain the peritumor tissue. PyRadiomics was used to extract the radiomic features. LASSO was used to select the features and tumor radiomics model, peritumor model and combined model were built using 5-fold cross-validation. And it was further tested on the independent cohort. Discrimination was assessed by using the C-index and area under the receiver operating characteristic curve (AUC), sensibility, specificity.
Interventions
OTHERtumor and peritumor radiomic feature
extracted the tumor and peritumor radiomic feature from the preoperative enhanced chest CT
Sponsors
Jinling Hospital, China
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* patients with T3 and T4 stage NSCLC； * available preoperative chest CTE within two weeks of surgery
Exclusion criteria
* inadequate imaging quality resulted from breathing artifact; * without regularly follow-up information on recurrence location and time
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| disease free time and recurrence location | until the December 2023 | the time from the surgery time to the recurrence time |
Countries
China
Outcome results
None listed